Napoleone Ferrara
Award Name : Canada Gairdner International Award
Year of Award : 2014
Award for : Medical
Location : San Diego, California, United States
Napoleone Ferrara, M.D. (born 26 July 1956, Catania), is an Italian-American molecular biologist who joined University of California, San Diego Moores Cancer Center in 2013 after a storied career in Northern California at the biotechnology giant Genentech, where he pioneered development of new treatments for cancer and age-related macular degeneration. There, he discovered VEGF—and made the first VEGF antibody—which suppresses growth of a variety of tumors. These findings helped lead to development of the first clinically available anti-angiogenesis inhibitor drug, bevacizumab (Avastin), which prevents the growth of new blood vessels into a solid tumor and which has become part of standard treatment for a variety of cancers.
Ferrara’s work led also to the development of ranibizumab (Lucentis), a drug that is highly effective at preventing vision loss in intraocular neovascular disorders.He received the Canada Gairdner International Award in 2014 for his discovering Vascular Endothelial Growth Factor (VEGF), a key molecular mediator of new blood vessel formation and the development of effective anti-VEGF therapy for cancer and wet macular degeneration.